A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins
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چکیده
منابع مشابه
A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins.
Pacemaker (HCN) channels have a key role in the generation and modulation of spontaneous activity of sinoatrial node myocytes. Previous work has shown that compartmentation of HCN4 pacemaker channels within caveolae regulates important functions, but the molecular mechanism responsible is still unknown. HCN channels have a conserved caveolin-binding domain (CBD) composed of three aromatic amino...
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Caveolins are coat proteins of caveolae, small flask-shaped pits of the plasma membranes of most cells. Aside from roles in caveolae formation, caveolins recruit, retain and regulate many caveolae-associated signalling molecules. Caveolin-protein interactions are commonly considered to occur between a ∼20 amino acid region within caveolin, the caveolin scaffolding domain (CSD), and an aromatic-...
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ژورنال
عنوان ژورنال: Journal of Molecular and Cellular Cardiology
سال: 2012
ISSN: 0022-2828
DOI: 10.1016/j.yjmcc.2012.05.013